PATHOGENETIC FEATURES OF THE MORPHOLOGICAL FACTOR OF TUBULAR INFERTILITY

Abstract: a comparative analysis of the results of a morphological study of 262 preparations of fallopian tubes was carried out, with an assessment of the ratio of intramural connective and muscle tissue, vascularization and the functional resource of microcirculation. Depending on the characteristics, the fallopian tubes were divided into 3 groups. Group I – 62 fallopian tubes obtained during postmortem examination of 36 women who died in road traffic accidents. In all cases, signs of inflammation of the reproductive organs and adhesions in the pelvic organs were absent. The results of the study were regarded as normative when interpreting the results in groups II and III. Group II – 112 fallopian tubes, which were removed during surgery for a chronic process in the fallopian tubes against the background of increased inflammation. Group III – 88 fallopian tubes, resected during tubal pregnancy. The preparation and staining of ultrathin preparations of the fallopian tubes for morphological examination were carried out according to standard methods. The preparations were stained with hematoxylin and eosin, according to Van Gieson, Gamory, and Gram-Weigert. The analysis criteria were changes in the quantitative indicators of connective tissue, muscle layer, total number of intramural vessels, functionally active and inactive elements of the microvasculature. Against the background of a chronic inflammatory process in the stage of exacerbation and in tubal pregnancy, there is an increase in the specific gravity of connective tissue in the lamina propria of the mucous membrane. Reducing the specific gravity of the intramural muscle layer, creating the prerequisites for disrupting the transport function of the fallopian tubes, due to a decrease in their propulsive capacity. The importance of morphological changes in the structure and decreased blood supply to the uterine vessels against the background of a chronic inflammatory process in the uterine appendages as a factor in the development of tubal and tubo-peritoneal infertility due to impaired transport function of the fallopian tubes, even while maintaining their patency is pathogenetically substantiated.

Keywords: inflammation, infertility, tubal pregnancy, fallopian tubes, connective tissue, muscle tissue, intramural vascularization, microcirculation

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