Abstract: the theoretical substantiation of the hypothesis about the negative role of the pathological cervical-genital inhibitory reflex as a factor in the inefficiency of artificial intrauterine insemination is carried out. So, during artificial intrauterine insemination, intracervical and intrauterine interventions are performed, which can cause a source of pathological impulse, that is, a factor that reduces the likelihood of pregnancy. The appearance of a focus of pathological impulse in the reflexogenic zone of the cervix and its distribution intramurally, like an axon reflex and is mediated through the retroperitoneal sacral and coccygeal plexuses, leads to dysfunction and discoordination of the endometrial motor activity. Against this background, a cervical-genital inhibitory reflex develops, creating the prerequisites for the inefficiency of intrauterine insemination. Based on this, a study was conducted of the results of intrauterine insemination in 164 women of reproductive age, depending on the intensity of the cervical-genital inhibitory reflex. The criteria for analysis were indicators of echo hysteroscopy before and after artificial intrauterine insemination and the frequency of pregnancy. Group I included 93 (100%) women who, after artificial intrauterine insemination, developed severe dysfunction of endometrial motor activity. Group II included 71 (100%) women who, after performing artificial intrauterine insemination, did not experience discoordination of endometrial peristaltic waves against the background of increased motor activity of the endometrium. A comparative analysis of the results of infertility treatment in the study groups using artificial intrauterine insemination showed that the frequency of pregnancy in group II, where marked dysfunction and discoordination of peristaltic activity of the endometrium was significantly less than in group I, where discoordination of motor activity of the endometrium was not observed (P <0.05). The results obtained indicate the pathogenetic significance of the cervical-genital inhibitory reflex, as a factor in reducing the effectiveness of IWMI and the prospects of research in this direction.
Keywords: infertility, pregnancy, intrauterine insemination, echo hysteroscopy, cervical-genital inhibitory reflex