Abstract: the insufficient effectiveness of traditional methods of treatment and the steady growth of non-specific inflammatory diseases of the uterine appendages indicates the need to find new ways to overcome microflora resistance to antibacterial drugs and to correct systemic disorders of homeostasis at the body level. A promising direction in solving this problem is the use of ozone therapy, which provides not only expressed antibacterial, but also detoxification and antioxidant effects. A comparative analysis of the results of changes in the parameters of lipid peroxidation and AOS in 60 patients during the treatment of NVZPM was carried out taking into account the use of local and systemic ozone therapy. All patients examined in our article were provided with information about the features, goals and objectives of the research program, written informed consent was obtained to participate in it, and a bilateral agreement on non-disclosure of personal data was additionally signed. Depending on the implementation of ozone therapy in the treatment of NVZPM, 2 groups were formed. In group I, which consisted of 30 women, complex treatment was carried out in the treatment of NVZPM, including injecting antibiotics, infusion therapy, vitamin therapy, and general strengthening treatment, after the acute inflammatory process subsided physiotherapeutic procedures. In group II, consisting of 30 patients with NVZPM, a similar treatment was carried out and, in addition, local and systemic ozone therapy. That is, in group II, the traditional treatment of NVZPM was carried out in combination with intravenous implementation of ozonized solutions and local vaginal sanitation with an ozonized 0.9% NaCl solution and insufflation with an ozone-oxygen mixture with an ozone concentration of 5 μg / L in it. To assess the dynamics of the pathological process, depending on the characteristics of the treatment, nonspecific biochemical indicators of inflammation of AlAT, AsAT, LPO and AOA, and SMP were determined. the inclusion of local and systemic ozone therapy in the complex therapy of NVZPM is pathogenetically justified, as it provides a significantly faster decrease in inflammatory phenomena, lipid peroxidation, and against the background of normalization of antioxidant activity at the body level, restoration of aerobic catabolism and reduction of endogenous intoxication.
Keywords: uterine appendages, inflammation, antibiotic resistance, ozone therapy, lipid peroxidation, antioxidant activity, medium molecular weight peptides, endogenous intoxication