Abstract: in the experiment, 3 series of studies aimed at identifying the role of chronic venous and lymphatic venous insufficiency in the development and chronicity of the infectious pathology of the vagina were carried out. In a series of experimental studies on 10 animals, a bacterioscopic examination of vaginal smears and the identification of quantitative indicators of “key cells” (QC) in them was carried out without modeling CVI and HLVN. In the second series of the experiment on 10 animals, similar studies were carried out in modeling the CVI due to the disturbance of the outflow in the internal iliac vein. In the third series of the experiment on 10 animals, similar studies were carried out in simulating HLVN using the method developed by us. Before the operation and after 1, 2, 3 and 4 months after modeling CVI and HLVN, material was taken from the vagina for microscopic examination. The criteria for analysis was the change in the ratio of the normal microflora of the vagina to the rest of its representatives and the number of key cells (QC). It was established that microcirculatory disorders develop in the background of modeling and development of HLVN, which are accompanied by stagnation of blood and lymph in the pelvic organs, hypoxia and mediated reduction of resistance vaginal mucosa to the microflora. In turn, this creates prerequisites for the development and chronicity of the infectious pathology of the vagina. Moreover, on the background of CVI, microbiocenosis and resistance of the vaginal mucosa to the microflora are less expressed than in HLVN and can be compensated for by the collateral lymph outflow, which reduces the risk and severity of dysbiotic disorders and reduced function of the vaginal mucous membrane immune system. It is advisable to continue research in this direction.
Keywords: vaginosis, key cells, vaginal dysbiosis, venous insufficiency, lymphovenous insufficiency, experiment