Abstract: this paper presents the results of treatment of 185 patients with acute drug-induced gastrointestinal ulcers, complicated by bleeding as well as focuses on the analysis of the incidence rate for this pathology and possibilities for its correction.
Gastroduodenal ulcers are the most common source of bleeding in the upper gastrointestinal tract and occupy more than 50% of them. Among the factors influencing the development of inflammatory and destructive lesions of the mucous membrane of the gastroduodenal zone, non-steroidal anti-inflammatory drugs (NSAIDs) take the second place after Helicobacter pylori.
We analyzed the data of the center, which is located on the basis of the abdominal surgery department of the regional clinical hospital, for the period from 2015 to 2019. The duration of administration of drugs ranged from 2-3 days to 6 years. An ulcerative history was established in 75 patients. Regardless of the severity of the condition, all patients in whom bleeding occurred while taking ulcerogenic medications are indicated for conservative treatment, including the correction of blood loss, the introduction of proton pump inhibitors.
Bleeding, could not be stopped conservatively, was subject to surgical correction. The following operations were performed on 28 patients with exacerbation of a chronic ulcer: ulcer excision with duodenoplasty was performed in 11 patients, sectoral gastrectomy in 6 patients, Billroth gastrectomy – 1 in 5 patients, ulcer externalization in 4 patients and ulcer piercing in 2 patients. No postoperative complications were observed, patients in satisfactory condition were discharged from the hospital.
Keywords: acute drug-induced ulcers, bleeding