Abstract: AIDS-associated diseases develop in the late stages of HIV infection, often become generalized and can be combined with each other. This creates difficulties in clinical, laboratory and morphological diagnosis of these diseases. The paper presents a pathomorphological study of 74 patients with the main diagnosis of HIV infection who were hospitalized. Pathomorphological study included: autopsy of deceased patients, description of macro-and microscopic changes in internal organs, histological, bacteriological, virological and molecular genetic studies of pathological material. Verification of HIV infection was performed by enzyme immunoassay and immunoblotting. The study revealed: a large number of late-detected among the deceased HIV-infected patients. According to clinical and morphological data, severe pathology of the respiratory system prevailed in dead patients. Bacterial pneumonia was recorded at the 1st place in the frequency of occurrence, fungal lesions were less common and viral lesions of the respiratory system were much less common. Not infrequently, the defeat of the respiratory system was associated with several pathogens simultaneously. The clinical and morphological picture of tuberculosis clearly depended on the stage of HIV infection. In the early stages of HIV infection, tuberculosis was characterized by an isolated thoracic process, in the later stages – malignancy and a rapidly progressive course with the involvement of many organs and systems in the pathological process. For a detailed study of morphological changes in AIDS-associated diseases it is necessary to use the largest possible range of different colors. Staining of pathological materials by cyl-Nielsen should be mandatory for all HIV-infected patients, taking into account the different clinical and morphological picture of tuberculosis in HIV-infected at different stages of the disease.

Keywords: HIV infection, late stages, AIDS-associated diseases, pathomorphology