PATHOGENETIC FEATURES OF THE INFLUENCE OF COVID-19 ON SPERM FERTILITY

Abstract: analysis of the results of sperm analysis in 62 men planning to participate in the IVF program. All subjects gave written informed consent to participate in the sperm fertility research program before and after the quarantine for the COVID-19 pandemic. Before the quarantine began in February-March 2020, they all underwent a comprehensive examination, including a study of sperm fertility and a PCR test for COVID-19. At the same time, all participants in the study program had normal spermogram results and negative PCR tests for the presence of COVID-19 coronavirus infection. Re-examination was carried out in August-September 2020. Depending on the results of a serological test for the presence of antibodies to COVID-19, the study participants were divided into 2 groups. Group I included 30 men in whom antibodies to COVID-19 were not detected in the blood during the ELISA (enzyme-linked immunosorbent assay) study. Group II consisted of 32 men in whom Ig G to COVID-19 was detected upon repeated blood tests. IgM results were negative. The criteria for the analysis, when performing our work, were the volume of sperm, its viscosity, liquefaction, the results of pH-metry, the quantitative indicators of spermatozoa, spermatogenesis cells and sperm agglutination in the test material, as well as their mobility. It is these indicators that are most vulnerable to the development of oxidative stress, which is a complication characteristic of SARS-COVID-19. It was found that in group II, compared with the results in group I, there was a significant decrease in the total number of spermatozoa and their content in 1 ml, as well as a decrease in the motor activity of spermatozoa. That is, both oligozoospermia and asthenozoospermia took place, which indicated a decrease in sperm fertility after the transferred, even in the asymptomatic version of COVID-19. It is advisable to continue research in this direction.

Keywords: sperm fertility, SARS-COVID-19, oligozoospermia, asthenozoospermia, azoospermia

melnikov