{"id":9475,"date":"2019-08-18T18:04:31","date_gmt":"2019-08-18T15:04:31","guid":{"rendered":"http:\/\/ijmp.ru\/?p=9475"},"modified":"2019-08-18T18:04:57","modified_gmt":"2019-08-18T15:04:57","slug":"dvustoronnjaja-targetnaja-terapija-ot-onko-i-infekcionnyh-patologij-k-autoimmunnym-zabolevanijam","status":"publish","type":"post","link":"https:\/\/ijmp.ru\/en\/archives\/9475","title":{"rendered":"BILATERAL TARGETED THERAPY: FROM CANCER AND  INFECTIOUS PATHOLOGIES TO AUTOIMMUNE DISEASES"},"content":{"rendered":"<p><strong>Abstract:<\/strong> the article analyzes forms of targeted therapy in the context of autoimmune pathologies. The molecular basis of modern targeted therapy \u2013 protein, DNA-analogs, protein-(DNA-analogs) constructs was outlined; genetic mechanisms of autoimmune pathologies. In relation to the latter, the use of bilateral targeted therapy is modeled and justified: antisense oligonucleotides are unique for each patient to block gene expression of the corresponding unique variable regions of autoreactive T and\/or B lymphocytes.<\/p>\n<p><strong>Keywords:<\/strong> autoimmune pathologies, lymphocyte\u2019s genomes variable regions, targeted therapy, bilateral targeted therapy, antisense oligonucleotides, artificially acquired personal passive genome immunity<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: the article analyzes forms of targeted therapy in the context of autoimmune pathologies. The molecular basis of modern targeted therapy \u2013 protein, DNA-analogs, protein-(DNA-analogs) constructs was outlined; genetic mechanisms of autoimmune pathologies. In relation to the latter, the use of bilateral targeted therapy is modeled and justified: antisense oligonucleotides are unique for each patient [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,23,27],"tags":[137,138,139,140,141],"class_list":["post-9475","post","type-post","status-publish","format-standard","hentry","category-publications","category-2019g","category-tom-2-3","tag-haraeva-z-f","tag-tlupova-t-g","tag-dzhanibekova-u-h","tag-kesheva-d-a","tag-dzhanibekov-k-h"],"translation":{"provider":"WPGlobus","version":"3.0.0","language":"en","enabled_languages":["ru","en"],"languages":{"ru":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false}}},"_links":{"self":[{"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/posts\/9475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/comments?post=9475"}],"version-history":[{"count":2,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/posts\/9475\/revisions"}],"predecessor-version":[{"id":9479,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/posts\/9475\/revisions\/9479"}],"wp:attachment":[{"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/media?parent=9475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/categories?post=9475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ijmp.ru\/en\/wp-json\/wp\/v2\/tags?post=9475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}